(−)-α-Bisabolol inhibits preferentially electromechanical coupling on rat isolated arteries
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چکیده
منابع مشابه
Effect of a novel stobadine derivative on isolated rat arteries
The antioxidant and reactive-oxygen-species-scavenging activity of stobadine has been demonstrated in previous studies. Recently, chemical modification of this leading structure led to the synthesis of other pyridoindole derivatives with significantly increased intrinsic antioxidant efficacy. Further structural modifications of stobadine provided the opportunity to increase bioavailability and ...
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Bradykinin is a potent vasodilator peptide; however, its half-life in vivo is very short because of various plasma and tissue peptidases that hydrolyze bradykinin to inactive fragments. We studied the role of kininase II (angiotensin converting enzyme) and neutral endopeptidase 24.11 (enkephalinase) in the catabolism of bradykinin in vascular tissue by determining the effect of inhibitors of ki...
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Propofol is a widely used anesthetic. Many studies have shown that propofol has direct effects on blood vessels, but the precise mechanism is not fully understood. Secondary intrapulmonary artery rings from male rats were prepared and mounted in a Multi Myograph System. The following constrictors were used to induce contractions in isolated artery rings: high K(+) solution (60 mmol/L); U46619 s...
متن کاملElectromechanical coupling I. Introduction.
In skeletal muscle fibres contraction is initiated by the action potential which travels inward along the transverse tubular system and causes in some way the release of Ca from the terminal cisternae of the sarcoplasmic reticulum (SR). Ca-release is probably controlled by a potential-sensor (intram em brane charge movement) in the wall of the T-system which in a triad is about 10 20 nm apart f...
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Hyperinsulinemia is a risk factor for hypertension and arteriosclerosis. The mechanism by which it contributes to disease progression is not known. The present study examines the effects of insulin on endothelium-derived relaxing factors. Segments of rat mesenteric arterioles and aorta were set up for isometric recordings. The effect of insulin (1 mU/mL) on acetylcholine responses was examined ...
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ژورنال
عنوان ژورنال: Vascular Pharmacology
سال: 2014
ISSN: 1537-1891
DOI: 10.1016/j.vph.2014.06.006